Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26453218 | 0.76 | TGFBR1 (0.60) | MAPK14CSNK1A1TGFBR1TGFBR2ABL2 | |
| SCHEMBL30919457 | 0.76 | TGFBR1 (0.60) | MAPK14CSNK1A1TGFBR1TGFBR2ABL2 | |
| SCHEMBL2814353 | 0.68 | HSP90AA1 (0.52) | MAPK14MAPK10MAPK9EGFRPRKACA | |
| SCHEMBL30595872 | 0.68 | HSP90AA1 (0.52) | MAPK14MAPK10MAPK9EGFRPRKACA | |
| SCHEMBL29941574 | 0.68 | MAPK10 (1.00) | MAPK14MAPK10MAPK9EGFRPRKACA | |
| SCHEMBL14519519 | 0.68 | MAPK14 (0.74) | MAPK14MAPK10MAPK9EGFRPRKACA | |
| SCHEMBL27217254 | 0.67 | DYRK1A (0.42) | MAPK14PRKACAGSK3BMINK1MAP4K5 | |
| SCHEMBL27075642 | 0.67 | CHUK (0.45) | MAPK14MAPK10MAPK9GSK3BPRKD3 | |
| SCHEMBL13910999 | 0.66 | HSP90AA1 (0.50) | MAPK14MAPK10MAPK9EGFRPRKACA | |
| SCHEMBL15500845 | 0.66 | PDPK1 (0.52) | MAPK14MAPK10MAPK9EGFRPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024227104-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BRAF VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |