SCHEMBL31119

SCHEMBL31119

COc1ccc(C(=O)c2nc3ccc(O)cc3s2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 8/20 0.65
HSD17B2 P37059 8/20 0.65
CYP1A2 P05177 2/20 0.65
CYP3A4 P08684 2/20 0.65
CYP2D6 P10635 2/20 0.65
CYP2C9 P11712 2/20 0.65
CYP2B6 P20813 2/20 0.65
CYP2C19 P33261 2/20 0.65
SULT1A1 P50225 1/20 0.60
MAOB P27338 6/20 0.58
SCD O00767 2/20 0.52
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
MAPT P10636 1/20 0.49
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
RXFP1 Q9HBX9 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8404873 0.92 HSD17B1 (0.72) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6
SCHEMBL31410 0.91 HSD17B1 (0.73) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6
SCHEMBL8400516 0.88 HSD17B1 (0.64) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6
SCHEMBL30049 0.87 HSD17B1 (0.76) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6
SCHEMBL8403934 0.87 HSD17B1 (0.65) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6
SCHEMBL8401031 0.86 HSD17B1 (0.74) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6
SCHEMBL8402862 0.85 HSD17B1 (0.74) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6
SCHEMBL8402858 0.84 HSD17B1 (0.69) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL8405370 0.84 HSD17B1 (0.74) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6
SCHEMBL8402863 0.84 HSD17B1 (0.68) HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025638-A1 SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS Universität des Saarlandes (DE) 2012-03-01 WO disclosed
CN-1063443-C Novel benzothiazole derivatives NIPPON INTERNAL ORGANS PHARMAC (JP) 2001-03-21 CN disclosed
US-5900426-A ANTILIPEMIC AGENTS NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 1999-05-04 US disclosed
EP-0735029-B1 Benzothiazole derivatives NIPPON ZOKI PHARMACEUTICAL CO (JP) 1998-06-03 EP disclosed
CN-1137524-A Novel benzothiazole derivatives NIPPON INTERNAL ORGANS PHARMAC (JP) 1996-12-11 CN disclosed
EP-0735029-A1 Benzothiazole derivatives NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 1996-10-02 EP disclosed