Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 20/20 | 1.00 |
| ▸ | HSD17B2 | P37059 | 17/20 | 1.00 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23443 | 0.88 | HSD17B1 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL23374 | 0.85 | HSD17B1 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL31434 | 0.83 | HSD17B1 (0.79) | HSD17B1HSD17B2CLK1DYRK1ADYRK1B | |
| SCHEMBL24752 | 0.80 | HSD17B1 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL26606781 | 0.78 | HSD17B1 (0.64) | HSD17B1HSD17B2CLK1DYRK1ADYRK1B | |
| SCHEMBL23686 | 0.77 | HSD17B1 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL22709 | 0.75 | HSD17B1 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL18186517 | 0.74 | HSD17B1 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL23409 | 0.73 | HSD17B2 (0.61) | HSD17B1HSD17B2 | |
| SCHEMBL23023 | 0.72 | HSD17B1 (1.00) | HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |