Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31128519 | 0.86 | PAX8 (0.46) | NOTUMSCDSCD5PAX8MAPK1 | |
| SCHEMBL31128539 | 0.86 | PAX8 (0.46) | NOTUMSCDSCD5PAX8MAPK1 | |
| SCHEMBL31128619 | 0.81 | MAPK1 (0.48) | SCDSCD5MAPK1NPC1RAB9A | |
| SCHEMBL31128567 | 0.80 | NOTUM (0.49) | NOTUMCHEK1AURKADAPK3JAK2 | |
| SCHEMBL2763829 | 0.80 | NOTUM (0.53) | NOTUMCHEK1AURKADAPK3JAK2 | |
| SCHEMBL31128642 | 0.78 | NOTUM (0.50) | NOTUMCHEK1AURKADAPK3JAK2 | |
| SCHEMBL8196656 | 0.78 | NOTUM (0.64) | NOTUMNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL31128525 | 0.76 | NOTUM (0.43) | NOTUMCHEK1AURKADAPK3JAK2 | |
| SCHEMBL31128603 | 0.76 | NOTUM (0.43) | NOTUMCHEK1AURKADAPK3JAK2 | |
| SCHEMBL2431070 | 0.76 | NOTUM (0.70) | NOTUMCHEK1AURKADAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173343-A1 | COMPOUNDS TARGETING HYDROXYSTEROID 17-BETA DEHYDROGENASE (HSD17B) AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2024-08-22 | — | — | WO | disclosed |