Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765509 | 0.84 | CYP3A4 (0.45) | MAPTSMN1; SMN2CYP3A4CYP2C19KDM4E | |
| SCHEMBL2765382 | 0.81 | TP53 (0.49) | MAPTSMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL31128642 | 0.80 | NOTUM (0.50) | NOTUMMAPTSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL31128488 | 0.80 | NOTUM (0.56) | NOTUMMAPTSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL31128603 | 0.78 | NOTUM (0.43) | NOTUMMAPTSMN1; SMN2CHEK1AURKA | |
| SCHEMBL31128525 | 0.78 | NOTUM (0.43) | NOTUMMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL2767252 | 0.77 | KDM4E (0.49) | SMN1; SMN2CYP3A4CYP2C19KDM4EHSD17B10 | |
| SCHEMBL13362367 | 0.77 | PTGS2 (0.56) | MAPTSMN1; SMN2CYP3A4CYP2C19KDM4E | |
| SCHEMBL31128567 | 0.76 | NOTUM (0.49) | NOTUMMAPTKDM4EHPGDCHEK1 | |
| SCHEMBL8196656 | 0.76 | NOTUM (0.64) | NOTUMMAPTSMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| CN-100491355-C | Cyclic diamine compound having five-membered cyclic group | KOWA CO (JP) | 2009-05-27 | — | — | CN | disclosed |
| CN-1522250-A | Cyclic diamine compound having five-membered cyclic group | ������������ʽ���� | 2004-08-18 | — | — | CN | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |