SCHEMBL31128917

SCHEMBL31128917

COCc1cc(N)ccc1B1OC(C)(C)C(C)(C)O1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
HTT P42858 1/20 0.33
F11 P03951 1/20 0.33
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
LPL P06858 1/20 0.31
LIPG Q9Y5X9 1/20 0.31
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23057746 0.83 LPL (0.37) MAPK1F11CA1CA2CA9
SCHEMBL30773539 0.81 BACE1 (0.32)
SCHEMBL27298762 0.80 LPL (0.45) F11LPLLIPG
SCHEMBL15011434 0.78 CYP1A2 (0.37)
SCHEMBL16110105 0.78 TDP2 (0.33) GAA
SCHEMBL29178976 0.78 ESR2 (0.33) F11LPLLIPG
SCHEMBL3922689 0.78 LPL (0.40) TSHRHTTF11LPLLIPG
SCHEMBL1356708 0.76 MAPT (0.43) GAAMAPTTSHRMAPK1HTT
SCHEMBL29973992 0.76 MAPT (0.43) GAAMAPTTSHRMAPK1HTT
SCHEMBL30615797 0.76 CXCR2 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024208315-A1 AROMATIC HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF 中国医药研究开发中心有限公司 2024-10-10 WO disclosed