⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31129386 | 0.86 | NPC1 (0.31) | — | |
| SCHEMBL27225244 | 0.80 | NPC1 (0.31) | — | |
| SCHEMBL31129559 | 0.76 | NPC1 (0.33) | — | |
| SCHEMBL31129470 | 0.70 | CRBN (0.41) | — | |
| SCHEMBL31129599 | 0.70 | ALDH1A1 (0.32) | — | |
| SCHEMBL24607353 | 0.69 | DGAT1 (0.35) | — | |
| SCHEMBL13015494 | 0.64 | DPP4 (0.38) | — | |
| SCHEMBL31129761 | 0.64 | NPC1 (0.38) | — | |
| SCHEMBL25337708 | 0.64 | NPC1 (0.38) | — | |
| SCHEMBL25340473 | 0.64 | DPP4 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260109716-A1 | CEREBLON-BASED KRAS DEGRADING PROTACS AND USES RELATED THERETO | ARVINAS OPERATIONS, INC. (US) | 2026-04-23 | — | — | US | disclosed |
| EP-4655073-A2 | CEREBLON-BASED KRAS DEGRADING PROTACS ANS USES RELATED THERETO | Arvinas Operations, Inc. (US) | 2025-12-03 | — | — | EP | disclosed |
| US-12448399-B2 | Cereblon-based KRAS degrading PROTACs and uses related thereto | ARVINAS OPERATIONS, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| WO-2024159164-A2 | CEREBLON-BASED KRAS DEGRADING PROTACS ANS USES RELATED THERETO | ARVINAS OPERATIONS, INC. (US) | 2024-08-02 | — | — | WO | disclosed |