Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 13/20 | 0.49 |
| ▸ | CA1 | P00915 | 13/20 | 0.49 |
| ▸ | CA2 | P00918 | 13/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3112518 | 0.86 | CA2 (0.38) | CA9CA1CA2PTGS2P4HB | |
| SCHEMBL3113410 | 0.85 | CA9 (0.47) | CA9CA1CA2PTGS2 | |
| SCHEMBL3110554 | 0.85 | PTGS2 (0.46) | CA9CA1CA2PTGS2 | |
| SCHEMBL3114880 | 0.85 | CA1 (0.47) | CA9CA1CA2PTGS2 | |
| SCHEMBL3113018 | 0.84 | CA1 (0.51) | CA9CA1CA2PTGS2 | |
| SCHEMBL3098291 | 0.82 | ADORA2A (0.39) | CA9CA1CA2PTGS2ROCK2 | |
| SCHEMBL3102018 | 0.79 | PTGS2 (0.45) | CA9CA1CA2PTGS2 | |
| SCHEMBL3234915 | 0.76 | CA9 (0.47) | CA9CA1CA2 | |
| SCHEMBL3101995 | 0.74 | CA2 (0.45) | CA9CA1CA2PTGS2 | |
| SCHEMBL3112267 | 0.73 | PTGS2 (0.44) | CA9CA1CA2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
| WO-2008017932-A2 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | PFIZER PRODUCTS INC. (US) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | CA2, CA7, CA9 | CA9 3/4885CA1 7/4885CA2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.