Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113435 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3110297 | 0.89 | FFAR1 (0.56) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3115544 | 0.89 | FFAR1 (0.51) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3110307 | 0.89 | FFAR1 (0.56) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3115554 | 0.89 | FFAR1 (0.51) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3110984 | 0.89 | GSK3B (0.54) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3110979 | 0.89 | GSK3B (0.54) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3115372 | 0.87 | NR4A2 (0.54) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3115382 | 0.87 | NR4A2 (0.54) | SMN1; SMN2NPC1RAB9ACASP3SENP8 | |
| SCHEMBL3105582 | 0.86 | MAOB (0.52) | NPC1RAB9AFFAR1MAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312308-A1 | SUBSTITUTED ACETIC ACID DERIVATIVES | WYETH (US) | 2008-12-18 | — | — | US | claimed |
| US-20060247298-A1 | Substituted acetic acid derivatives | WYETH (US) | 2006-11-02 | — | — | US | claimed |
| US-7803835-B2 | Substituted acetic acid derivatives | WYETH LLC (US) | 2010-09-28 | — | — | US | disclosed |
| US-20080312308-A1 | SUBSTITUTED ACETIC ACID DERIVATIVES | WYETH (US) | 2008-12-18 | — | — | US | disclosed |
| US-7411083-B2 | Substituted acetic acid derivatives | WYETH (US) | 2008-08-12 | — | — | US | disclosed |
| US-20060247298-A1 | Substituted acetic acid derivatives | WYETH (US) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312308-A1 | SUBSTITUTED ACETIC ACID DERIVATIVES | AADAC, ACACA, AANAT | SMN1; SMN2 4152/4885NPC1 3290/4885RAB9A 1361/4885 |
| US-20060247298-A1 | Substituted acetic acid derivatives | AADAC, ACACA, AANAT | SMN1; SMN2 4152/4885NPC1 3290/4885RAB9A 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.