Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 4/20 | 0.56 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3121498 | 0.86 | GABBR2 (0.67) | GABBR2GABBR1ADORA1ADORA3ADORA2A | |
| SCHEMBL3112867 | 0.84 | GABBR2 (0.61) | GABBR2GABBR1ADORA1ADORA3ADORA2A | |
| SCHEMBL3124036 | 0.82 | MERTK (0.47) | GABBR2GABBR1ADORA1IRAK1TLR7 | |
| SCHEMBL3123747 | 0.80 | GABBR2 (0.75) | GABBR2GABBR1IRAK1TYRO3MERTK | |
| SCHEMBL3123882 | 0.78 | GABBR2 (0.60) | GABBR2GABBR1IRAK1TLR7TYRO3 | |
| SCHEMBL3118196 | 0.78 | GABBR2 (0.62) | GABBR2GABBR1ADORA1ADORA3ADORA2A | |
| SCHEMBL13248661 | 0.77 | GABBR2 (0.72) | GABBR2GABBR1IRAK1TLR7TYRO3 | |
| Hydrochloric Acid SCHEMBL3119417 | 0.76 | GABBR2 (0.70) | GABBR2GABBR1IRAK1TLR7TYRO3 | |
| SCHEMBL3115529 | 0.75 | GABBR2 (0.55) | GABBR2GABBR1TLR7TYRO3MERTK | |
| SCHEMBL3120412 | 0.75 | GABBR2 (0.77) | GABBR2GABBR1IRAK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179127-A1 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2010-07-15 | — | — | US | disclosed |
| US-20100179127-A1 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2010-07-15 | — | — | US | disclosed |
| US-20100179127-A1 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179127-A1 | PYRIMIDINE DERIVATIVES | DPYD, NUDT1, HPRT1 | GABBR2 1611/4885GABBR1 1499/4885ADORA1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.