Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2538401 | 0.82 | KDM4E (0.33) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL2121865 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1POLB | |
| SCHEMBL2121709 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1TDP1 | |
| SCHEMBL311517 | 0.78 | AKT1 (0.31) | — | |
| SCHEMBL2120939 | 0.78 | KDM4E (0.37) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL2120299 | 0.78 | METTL3 (0.41) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL2512855 | 0.78 | KDM4E (0.36) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL2533055 | 0.78 | KDM4E (0.35) | KDM4EALDH1A1 | |
| SCHEMBL2512319 | 0.77 | RXFP1 (0.32) | KDM4E | |
| SCHEMBL2122900 | 0.76 | KDM4E (0.34) | KDM4EALDH1A1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093255-B2 | Imidazo[1,2-A]pyrimidines as orexin receptor antagonists | GLAXO GROUP LIMITED (GB) | 2012-01-10 | — | — | US | disclosed |