Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | RECQL | P46063 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15450383 | 0.85 | KDM4E (0.55) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL19360100 | 0.85 | KDM4E (0.70) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL3111714 | 0.80 | RECQL (0.50) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL14587412 | 0.80 | CES2 (0.44) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL5659719 | 0.80 | CES2 (0.44) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL4337552 | 0.80 | CES2 (0.44) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL16169011 | 0.79 | CES2 (0.39) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL14100327 | 0.79 | CES2 (0.39) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL23232270 | 0.79 | CES2 (0.50) | ADRB1ADRA2AADRA2CCES2CES1 | |
| SCHEMBL4102499 | 0.79 | CES2 (0.50) | KDM4ERECQLTDP1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179221-A1 | FLUORINE-SUBSTITUTED AMPHETAMINES AND AMPHETAMINE DERIVATIVES AND USE THEREOF | UNIVERSITAT TUBINGEN (DE) | 2010-07-15 | — | — | US | disclosed |
| EP-2121571-A1 | FLUORINE-SUBSTITUTED AMPHETAMINES AND AMPHETAMINE DERIVATIVES AND USE THEREOF | Universität Tübingen (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008113565-A1 | FLUORINE-SUBSTITUTED AMPHETAMINES AND AMPHETAMINE DERIVATIVES AND USE THEREOF | Universität Tübingen (DE) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179221-A1 | FLUORINE-SUBSTITUTED AMPHETAMINES AND AMPHETAMINE DERIVATIVES AND USE THEREOF | DBH, SLC6A3, COMT | KDM4E 676/4885RECQL 814/4885TDP1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.