Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.41 |
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3104787 | 0.91 | CA2 (0.40) | CA2CA4SCN8ACA1PTGS2 | |
| SCHEMBL3115500 | 0.90 | CA2 (0.41) | CA2CA4SCN8APTGS2POLB | |
| SCHEMBL3106717 | 0.87 | CA2 (0.42) | CA2CA4SCN8ACA12CA1 | |
| SCHEMBL13099931 | 0.82 | PTGS2 (0.38) | CA2CA12CA1CA9PTGS2 | |
| SCHEMBL3109090 | 0.82 | PTGS2 (0.34) | CA2SCN8ACA12CA1CA9 | |
| SCHEMBL13100421 | 0.81 | DRD4 (0.38) | CA2CA4CA12CA1CA9 | |
| SCHEMBL3095873 | 0.81 | CA2 (0.41) | CA2CA4CA12CA1CA9 | |
| SCHEMBL3117149 | 0.81 | PTGS2 (0.33) | CA2SCN8ACA12CA1CA9 | |
| SCHEMBL13100438 | 0.81 | CA1 (0.37) | CA2CA4CA12CA1CA9 | |
| SCHEMBL13100419 | 0.80 | CA1 (0.49) | CA2CA4CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | CA2, CA7, CA9 | CA2 1/4885CA4 4/4885SCN8A 827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.