Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31160541 | 0.88 | GRM2 (0.44) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160527 | 0.81 | GRM2 (0.47) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160524 | 0.76 | PIK3CD (0.45) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160512 | 0.74 | PDE3B (0.48) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160519 | 0.74 | PIK3CD (0.46) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL30915406 | 0.73 | TDP2 (0.59) | GRM2TDP2PIM1GRM5DAPK3 | |
| SCHEMBL31160529 | 0.73 | PIK3CD (0.42) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160522 | 0.73 | PDE3B (0.46) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160534 | 0.72 | MAPK14 (0.46) | GRM2PIK3CDPIK3CBTDP2 | |
| SCHEMBL18863211 | 0.69 | GRM2 (0.50) | GRM2PIK3CDPIK3CBPIK3CAPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4673136-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | Vanderbilt University (US) | 2026-01-07 | — | — | EP | disclosed |
| WO-2024182692-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2024-09-06 | — | — | WO | disclosed |