Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31160535 | 0.81 | GRM2 (0.45) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160524 | 0.81 | PIK3CD (0.45) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160541 | 0.80 | GRM2 (0.44) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31159005 | 0.77 | GRM2 (0.46) | GRM2PIK3CDPIK3CBPIK3CAMAPK14 | |
| SCHEMBL31160512 | 0.76 | PDE3B (0.48) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160519 | 0.76 | PIK3CD (0.46) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL30915406 | 0.75 | TDP2 (0.59) | GRM2TDP2GRM5NTRK1FLT3 | |
| SCHEMBL31160529 | 0.75 | PIK3CD (0.42) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL31160522 | 0.75 | PDE3B (0.46) | GRM2PIK3CDPIK3CBTDP2PIK3CA | |
| SCHEMBL18863211 | 0.71 | GRM2 (0.50) | GRM2PIK3CDPIK3CBPIK3CAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4673136-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | Vanderbilt University (US) | 2026-01-07 | — | — | EP | disclosed |
| WO-2024182692-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2024-09-06 | — | — | WO | disclosed |