SCHEMBL31171017

SCHEMBL31171017

CC(C)(C)OC(=O)N1CC[C@H](Nc2ncc(C(F)(F)F)cc2N)C1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 2/20 0.51
BTK Q06187 1/20 0.48
USP30 Q70CQ3 5/20 0.46
RIPK1 Q13546 2/20 0.46
SYK P43405 1/20 0.45
STS P08842 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
CYP3A4 P08684 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C9 P11712 2/20 0.43
HSD11B1 P28845 2/20 0.43
PIK3CA P42336 1/20 0.43
ADORA1 P30542 1/20 0.43
IDH1 O75874 1/20 0.43
SCN9A Q15858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29124439 1.00 PIK3CD (0.51) PIK3CDBTKUSP30RIPK1SYK
SCHEMBL7178421 1.00 PIK3CD (0.51) PIK3CDBTKUSP30RIPK1SYK
SCHEMBL7178416 1.00 PIK3CD (0.51) PIK3CDBTKUSP30RIPK1SYK
SCHEMBL29124358 0.87 PIK3CD (0.53) PIK3CDBTKUSP30PIK3CAADORA1
SCHEMBL29124357 0.87 PIK3CD (0.53) PIK3CDBTKUSP30PIK3CAADORA1
SCHEMBL31170908 0.87 PIK3CD (0.53) PIK3CDBTKUSP30PIK3CAADORA1
SCHEMBL2636499 0.86 PIK3CD (0.52) PIK3CDBTKUSP30HSD11B1PIK3CA
SCHEMBL2636502 0.86 PIK3CD (0.52) PIK3CDBTKUSP30HSD11B1PIK3CA
SCHEMBL21811035 0.85 PIK3CD (0.43) PIK3CDBTKCYP3A4CYP2D6CYP2C9
SCHEMBL21811034 0.85 PIK3CD (0.43) PIK3CDBTKCYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240425504-A1 IMIDAZOPYRIDINONE COMPOUND KISSEI PHARMACEUTICAL CO., LTD. (assignee) (JP) 2024-12-26 US disclosed
EP-3808747-B1 IMIDAZOPYRIDINONE COMPOUND KISSEI PHARMACEUTICAL (JP) 2024-12-18 EP disclosed
US-12077531-B2 Imidazopyridinone compound KISSEI PHARMACEUTICAL CO., LTD. (JP) 2024-09-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12077531-B2 Imidazopyridinone compound EGLN3, DHPS, EGLN2 PIK3CD 2844/4885BTK 1827/4885USP30 716/4885
US-20240425504-A1 IMIDAZOPYRIDINONE COMPOUND EGLN3, DHPS, EGLN2 PIK3CD 2844/4885BTK 1827/4885USP30 716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.