Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31580332 | 0.86 | CYP11B1 (0.40) | OPRM1OPRL1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL31622174 | 0.83 | SMN1; SMN2 (0.34) | OPRM1OPRL1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL16600431 | 0.83 | SMN1; SMN2 (0.34) | OPRM1OPRL1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL289351 | 0.81 | OPRM1 (0.42) | OPRM1OPRL1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL18690046 | 0.76 | CYP11B1 (0.39) | OPRM1OPRL1CYP11B1CYP11B2 | |
| SCHEMBL17925559 | 0.75 | DDB1 (0.42) | SMN1; SMN2CYP11B2 | |
| SCHEMBL26112063 | 0.74 | LMNA (0.35) | — | |
| SCHEMBL29626701 | 0.74 | CYP11B1 (0.39) | OPRM1OPRL1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL23260104 | 0.74 | SMN1; SMN2 (0.39) | OPRM1OPRL1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL21673246 | 0.74 | SMN1; SMN2 (0.43) | OPRM1OPRL1SMN1; SMN2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876928-B1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | MERCK SHARP & DOHME LLC (US) | 2024-10-23 | — | — | EP | claimed |
| EP-4746963-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025017045-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-23 | — | — | WO | disclosed |