SCHEMBL31178048

SCHEMBL31178048

O=C1CCC(NC(=O)c2cccc3[nH]c(Cl)nc23)C(=O)N1

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 19/20 0.58
▸ BRD4 O60885 2/20 0.58
▸ DDB1 Q16531 4/20 0.52
▸ IKZF3 Q9UKT9 1/20 0.47
▸ PARP1 P09874 1/20 0.43
▸ PARP2 Q9UGN5 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23453398 1.00 CRBN (0.58) CRBNBRD4DDB1IKZF3PARP1
SCHEMBL23453409 0.87 CRBN (0.59) CRBNBRD4DDB1IKZF3PARP1
SCHEMBL29894574 0.87 CRBN (0.59) CRBNBRD4DDB1IKZF3PARP1
SCHEMBL23453410 0.84 CRBN (0.55) CRBNBRD4DDB1IKZF3PARP1
SCHEMBL24745182 0.84 CRBN (0.55) CRBNBRD4DDB1IKZF3PARP1
SCHEMBL31178044 0.84 CRBN (0.55) CRBNBRD4DDB1IKZF3PARP1
SCHEMBL23453403 0.84 CRBN (0.55) CRBNBRD4DDB1IKZF3
SCHEMBL23458427 0.83 CRBN (0.53) CRBNBRD4DDB1PARP1
SCHEMBL23453698 0.82 CRBN (0.52) CRBNBRD4DDB1IKZF3
SCHEMBL23453408 0.81 CRBN (0.52) CRBNBRD4DDB1IKZF3PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240343706-A1 PIPERIDINE-2,6-DIONE DERIVATIVES WHICH BIND TO CEREBLON, AND METHODS OF USE THEREOF CAPTOR THERAPEUTICS S. A. (PL) 2024-10-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240343706-A1 PIPERIDINE-2,6-DIONE DERIVATIVES WHICH BIND TO CEREBLON, AND METHODS OF USE THEREOF CRBN, CDR2, DRD2 CRBN 1/4885BRD4 449/4885DDB1 1161/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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