Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 7/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184909 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2CYP1A2CYP2C19MAPTALDH1A1 | |
| SCHEMBL31185073 | 0.87 | MAPT (0.39) | SMN1; SMN2CYP1A2CYP2C19NPC1CYP2C9 | |
| SCHEMBL31184879 | 0.84 | CHKA (0.42) | SMN1; SMN2CYP1A2CYP2C19HPGDMAPT | |
| SCHEMBL31184693 | 0.83 | MALT1 (0.45) | SMN1; SMN2CYP1A2CYP2C19MAPTALDH1A1 | |
| SCHEMBL31184968 | 0.83 | POLB (0.36) | SMN1; SMN2CYP1A2CYP2C19NPC1CYP2C9 | |
| SCHEMBL31184510 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP1A2CYP2C19HPGDMAPT | |
| SCHEMBL31184993 | 0.77 | CHKA (0.37) | SMN1; SMN2CYP1A2CYP2C19MAPTALDH1A1 | |
| SCHEMBL31184573 | 0.76 | MALT1 (0.46) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL31184462 | 0.75 | CYP3A4 (0.40) | SMN1; SMN2CYP1A2CYP2C19NPC1CYP2C9 | |
| SCHEMBL31184844 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP1A2CYP2C19NPC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220626-A1 | SMALL MOLECULE MODULATORS OF OGG1 | AZKARRA THERAPEUTICS, INC. (US) | 2024-10-24 | — | — | WO | disclosed |