Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 2/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14998792 | 0.78 | AGTR1 (0.44) | OXTRAVPR1AITGB1ITGA4ADAM17 | |
| SCHEMBL2181 | 0.76 | AGTR1 (0.47) | OXTRAVPR1AITGB1ITGA4LTB4R2 | |
| SCHEMBL2918 | 0.75 | AGTR1 (0.40) | OXTRAVPR1AITGB1ITGA4LTB4R2 | |
| SCHEMBL2630 | 0.75 | AGTR1 (0.40) | OXTRAVPR1AITGB1ITGA4LTB4R2 | |
| SCHEMBL2628 | 0.74 | LTB4R2 (0.54) | LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL2629 | 0.74 | LTB4R2 (0.54) | LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL1970 | 0.74 | LTB4R2 (0.51) | LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL10050910 | 0.73 | MME (0.41) | OXTRAVPR1AITGB1ITGA4MME | |
| SCHEMBL2432 | 0.73 | MYC (0.45) | OXTRAVPR1AITGB1ITGA4ADAM17 | |
| SCHEMBL2174 | 0.73 | MYC (0.45) | OXTRAVPR1AITGB1ITGA4ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |