Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3123679 | 0.80 | ALDH1A1 (0.70) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL4084506 | 0.80 | ALDH1A1 (0.67) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL562770 | 0.79 | ALDH1A1 (0.68) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL28928330 | 0.76 | ALDH1A1 (0.71) | ALDH1A1MAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL563216 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL2996159 | 0.76 | ALDH1A1 (0.45) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL28162015 | 0.70 | GAA (1.00) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL22378025 | 0.70 | MAPT (0.43) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL741750 | 0.69 | ALDH1A1 (0.71) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL6705746 | 0.68 | ALDH1A1 (1.00) | ALDH1A1MAPTKMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |