Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29418819 | 0.86 | KRAS (0.48) | KRAS | |
| SCHEMBL30704160 | 0.86 | KRAS (0.48) | KRAS | |
| SCHEMBL29418796 | 0.84 | KRAS (0.47) | KRAS | |
| SCHEMBL29680145 | 0.82 | KRAS (0.51) | KRAS | |
| SCHEMBL30391087 | 0.82 | KRAS (0.47) | KRAS | |
| SCHEMBL30391732 | 0.82 | KRAS (0.47) | KRAS | |
| SCHEMBL30391045 | 0.82 | KRAS (0.47) | KRAS | |
| SCHEMBL30704205 | 0.81 | KRAS (0.54) | KRAS | |
| Hydrochloric Acid SCHEMBL30391165 | 0.81 | KRAS (0.46) | KRAS | |
| SCHEMBL30704185 | 0.79 | KRAS (0.47) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240376128-A1 | N-CYCLOPROPYLPYRIDO [4, 3-D] PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240376128-A1 | N-CYCLOPROPYLPYRIDO [4, 3-D] PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | CYP4A11, CYP4B1, DHPS | KRAS 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.