Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 8/20 | 0.77 |
| ▸ | TTR | P02766 | 7/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | PGR | P06401 | 2/20 | 0.77 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.77 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.77 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.77 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.77 |
| ▸ | HTR1A | P08908 | 1/20 | 0.77 |
| ▸ | DRD1 | P21728 | 1/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.77 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.77 |
| ▸ | DRD3 | P35462 | 1/20 | 0.77 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7752224 | 0.88 | EYA3 (0.74) | EYA3TTRMEN1ABCB11LMNA | |
| Benziodarone SCHEMBL31326233 | 0.87 | EYA3 (1.00) | EYA3TTRMEN1ABCB11LMNA | |
| Benziodarone SCHEMBL308541 | 0.87 | EYA3 (1.00) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL6336681 | 0.86 | EYA3 (0.75) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL14192204 | 0.84 | THRA (0.68) | MEN1ABCB11LMNAADRA2AOPRM1 | |
| SCHEMBL15698032 | 0.84 | EYA3 (0.84) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL13522210 | 0.83 | EYA3 (0.69) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL6335384 | 0.82 | EYA3 (1.00) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL15698071 | 0.82 | EYA3 (1.00) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL14625446 | 0.82 | CYP2C19 (0.72) | EYA3TTRMEN1ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145881-A1 | Antiarrhythmic precursor compounds, methods of synthesis and methods of use | Aryx Therapeutics, Inc. (US) | 2010-01-20 | — | — | EP | disclosed |
| EP-2145881-A1 | Antiarrhythmic precursor compounds, methods of synthesis and methods of use | Aryx Therapeutics, Inc. (US) | 2010-01-20 | — | — | EP | disclosed |
| EP-1904502-B1 | ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE | ARYX THERAPEUTICS INC (US) | 2009-10-21 | — | — | EP | disclosed |
| EP-1904502-B1 | ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE | ARYX THERAPEUTICS INC (US) | 2009-10-21 | — | — | EP | disclosed |
| US-7498449-B2 | Antiarrhythmic precursor compounds, methods of synthesis and methods of use | ARYX THERAPEUTICS (US) | 2009-03-03 | — | — | US | disclosed |
| US-7498449-B2 | Antiarrhythmic precursor compounds, methods of synthesis and methods of use | ARYX THERAPEUTICS (US) | 2009-03-03 | — | — | US | disclosed |
| US-7498449-B2 | Antiarrhythmic precursor compounds, methods of synthesis and methods of use | ARYX THERAPEUTICS (US) | 2009-03-03 | — | — | US | disclosed |
| EP-1904502-A2 | ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE | Aryx Therapeutics, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| US-20070060640-A1 | Antiarrhythmic Precursor Compounds, Methods Of Synthesis And Methods Of Use | ARYX THERAPEUTICS (US) | 2007-03-15 | — | — | US | disclosed |
| US-20070060640-A1 | Antiarrhythmic Precursor Compounds, Methods Of Synthesis And Methods Of Use | ARYX THERAPEUTICS (US) | 2007-03-15 | — | — | US | disclosed |
| US-20070060640-A1 | Antiarrhythmic Precursor Compounds, Methods Of Synthesis And Methods Of Use | ARYX THERAPEUTICS (US) | 2007-03-15 | — | — | US | disclosed |
| WO-2007011835-A2 | ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE | ARYX THERAPEUTICS, INC. (US) | 2007-01-25 | — | — | WO | disclosed |
| US-6316487-B1 | FOR THERAPY OF VENTRICULAR TACHYARRHYTHMIAS, ESPECIALLY IN PATIENTS WITH CONGESTIVE HEART FAILURE AND VENTRICULAR ARRHYTHMIAS AND SUPRAVENTRICULAR ARRHYTHMIAS, INCLUDING ATRIAL FIBRILLATION AND RE-ENTRANT TACHYARRHYTHMIAS | ARYX THERAPEUTICS | 2001-11-13 | — | — | US | disclosed |
| US-6130240-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ARYX THERAPEUTICS, INC. (US) | 2000-10-10 | — | — | US | disclosed |
| EP-0703910-B1 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5440054-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ADVANCED THERAPIES, INC. (US) | 1995-08-08 | — | — | US | disclosed |
| US-5364880-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ADVANCED THERAPIES, INC. (US) | 1994-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060640-A1 | Antiarrhythmic Precursor Compounds, Methods Of Synthesis And Methods Of Use | SCN11A, SCN10A, CYP4F11 | EYA3 4600/4885TTR 757/4885MEN1 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.