Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 19/20 | 0.67 |
| ▸ | HTR2A | P28223 | 18/20 | 0.67 |
| ▸ | DRD2 | P14416 | 14/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1985406 | 1.00 | DRD3 (0.67) | DRD3HTR2ADRD2HTR1A | |
| SCHEMBL1989095 | 0.91 | DRD2 (0.68) | DRD3HTR2ADRD2HTR1A | |
| SCHEMBL3111194 | 0.91 | DRD2 (0.68) | DRD3HTR2ADRD2HTR1A | |
| SCHEMBL3112244 | 0.90 | HTR2A (0.63) | DRD3HTR2ADRD2 | |
| SCHEMBL1983216 | 0.90 | HTR2A (0.63) | DRD3HTR2ADRD2 | |
| SCHEMBL1983773 | 0.89 | DRD2 (0.56) | DRD3HTR2ADRD2 | |
| SCHEMBL3122644 | 0.89 | DRD2 (0.56) | DRD3HTR2ADRD2 | |
| SCHEMBL3112221 | 0.89 | DRD2 (0.55) | DRD3HTR2ADRD2HTR1A | |
| SCHEMBL3112228 | 0.89 | DRD2 (0.55) | DRD3HTR2ADRD2HTR1A | |
| SCHEMBL1969324 | 0.88 | DRD3 (0.67) | DRD3HTR2ADRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825123-B2 | Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2010-11-02 | — | — | US | claimed |
| US-20100075981-A1 | ISOXAZOLO[4,5]PYRIDIN-3-YL-PIPERAZIN DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS | HOFFMANN-LA ROCHE, INC. | 2010-03-25 | — | — | US | claimed |
| US-7825123-B2 | Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-7825123-B2 | Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-7825123-B2 | Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20100075981-A1 | ISOXAZOLO[4,5]PYRIDIN-3-YL-PIPERAZIN DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS | HOFFMANN-LA ROCHE, INC. | 2010-03-25 | — | — | US | disclosed |
| US-20100075981-A1 | ISOXAZOLO[4,5]PYRIDIN-3-YL-PIPERAZIN DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS | HOFFMANN-LA ROCHE, INC. | 2010-03-25 | — | — | US | disclosed |
| US-20100075981-A1 | ISOXAZOLO[4,5]PYRIDIN-3-YL-PIPERAZIN DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS | HOFFMANN-LA ROCHE, INC. | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075981-A1 | ISOXAZOLO[4,5]PYRIDIN-3-YL-PIPERAZIN DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS | DRD3, DRD2, HTR3A | DRD3 1/4885HTR2A 36/4885DRD2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.