Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31205685 | 1.00 | RIPK1 (0.38) | RIPK1DGAT2MTORPIK3CAPIK3CB | |
| SCHEMBL31205434 | 0.97 | RIPK1 (0.39) | RIPK1DGAT2MTORKDM4EALDH1A1 | |
| SCHEMBL31205525 | 0.92 | RIPK1 (0.40) | RIPK1DGAT2MTORKDM4E | |
| SCHEMBL31205424 | 0.87 | RIPK1 (0.39) | RIPK1DGAT2MTORKDM4EALDH1A1 | |
| SCHEMBL31205785 | 0.87 | RIPK1 (0.36) | RIPK1DGAT2KDM4EALDH1A1HPGD | |
| SCHEMBL31205537 | 0.86 | KDM4E (0.40) | RIPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL31205522 | 0.84 | RIPK1 (0.38) | RIPK1DGAT2KDM4EALDH1A1 | |
| SCHEMBL31205631 | 0.84 | OPRL1 (0.31) | — | |
| SCHEMBL31205628 | 0.83 | RIPK1 (0.39) | RIPK1MTORKDM4E | |
| SCHEMBL31205710 | 0.83 | RIPK1 (0.37) | RIPK1DGAT2MTORKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709723-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233544-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |