Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31205790 | 0.90 | RIPK1 (0.42) | RIPK1KDM4EPOLB | |
| SCHEMBL25816949 | 0.88 | RIPK1 (0.42) | RIPK1KDM4E | |
| SCHEMBL30338804 | 0.88 | RIPK1 (0.42) | RIPK1KDM4E | |
| SCHEMBL25295104 | 0.87 | RIPK1 (0.43) | RIPK1KDM4E | |
| SCHEMBL30339283 | 0.87 | RIPK1 (0.43) | RIPK1KDM4E | |
| SCHEMBL31205515 | 0.85 | RIPK1 (0.38) | RIPK1KDM4EALDH1A1RXFP1CYP2C19 | |
| SCHEMBL31205747 | 0.84 | RIPK1 (0.39) | RIPK1KDM4E | |
| SCHEMBL31205726 | 0.84 | RIPK1 (0.39) | RIPK1KDM4E | |
| SCHEMBL31205739 | 0.84 | RIPK1 (0.38) | RIPK1KDM4EALDH1A1KMT2ACYP2C19 | |
| SCHEMBL31205628 | 0.83 | RIPK1 (0.39) | RIPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709723-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233544-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |