SCHEMBL31207340

SCHEMBL31207340

Nc1ccc2c(N)n[nH]c2n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 3/20 0.46
ADORA2A P29274 2/20 0.46
CA5A P35218 1/20 0.46
PDPK1 O15530 10/20 0.42
GAA P10253 2/20 0.40
KDM4E B2RXH2 1/20 0.40
CYP3A4 P08684 1/20 0.40
JAK2 O60674 3/20 0.39
BACE1 P56817 1/20 0.35
CHEK1 O14757 1/20 0.35
FLT3 P36888 1/20 0.35
PLK3 Q9H4B4 1/20 0.35
KMT2A Q03164 1/20 0.34
AURKA O14965 2/20 0.34
TGFBR1 P36897 2/20 0.34
ROCK1 Q13464 2/20 0.34
AURKB Q96GD4 2/20 0.34
CHUK O15111 1/20 0.34
RPS6KB1 P23443 1/20 0.34
CDK2 P24941 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25475233 0.81 ADORA1 (0.50) ADORA1ADORA2ACA5APDPK1GAA
SCHEMBL32683505 0.81 ADORA1 (0.50) ADORA1ADORA2ACA5APDPK1GAA
SCHEMBL26675355 0.78 PDPK1 (0.46) ADORA1ADORA2APDPK1GAAKDM4E
SCHEMBL4565224 0.77 ADORA1 (0.42) ADORA1ADORA2ACA5APDPK1BACE1
SCHEMBL7425108 0.75 PDPK1 (0.35) PDPK1GAAKDM4ECYP3A4JAK2
SCHEMBL20916782 0.75 MAPK13 (0.47) ADORA1ADORA2ACA5APDPK1JAK2
SCHEMBL493663 0.75 ADORA1 (0.41) ADORA1ADORA2ACA5A
SCHEMBL31032821 0.74 CCR1 (0.41) PDPK1GAAKDM4ECYP3A4JAK2
SCHEMBL16680749 0.74 JAK2 (0.38) PDPK1GAAKDM4ECYP3A4JAK2
SCHEMBL26834986 0.74 PDPK1 (0.36) PDPK1GAAKDM4ECYP3A4JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024224297-A1 METHOD FOR PREPARING 4-AMINOINDAN AND METHOD FOR PREPARING DIHYDROINDENYL-PYRAZOLO[3,4-B]PYRIDINE-AMINE 제이더블유중외제약 주식회사 2024-10-31 WO disclosed
WO-2024224298-A1 METHOD OF PREPARING 4-AMINOINDAN AND METHOD OF PREPARING DIHYDROINDENYL-PYRAZOLO[3,4-B]PYRIDINE-AMINE COMPOUND 제이더블유중외제약 주식회사 2024-10-31 WO disclosed