Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA7 | P43166 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3120980 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL14963071 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3117963 | 0.86 | HPGD (0.45) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3117973 | 0.86 | HPGD (0.45) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3106288 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3116771 | 0.84 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3106284 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3116768 | 0.84 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3110499 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3110506 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1MAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782449-B1 | ISOXAZOLINE DERIVATIVES USED IN THE CONTROL OF ECTOPARASITES | ANACOR PHARMACEUTICALS INC (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2782449-A1 | ISOXAZOLINE DERIVATIVES USED IN THE CONTROL OF ECTOPARASITES | Anacor Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| US-8546357-B2 | Boron-containing small molecules for controlling ectoparasites | ELI LILLY AND COMPANY (US) | 2013-10-01 | — | — | US | disclosed |
| WO-2013078071-A1 | ISOXAZOLINE DERIVATIVES USED IN THE CONTROL OF ECTOPARASITES | ELI LILLY AND COMPANY (US) | 2013-05-30 | — | — | WO | disclosed |
| US-20130131017-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| US-8372867-B2 | Insecticidal aryl isoxazoline derivatives | BAYER CROPSCIENCE AG (DE) | 2013-02-12 | — | — | US | disclosed |
| US-20100179194-A1 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | BAYER CORPSCIENCE AG (DE) | 2010-07-15 | — | — | US | disclosed |
| EP-2181100-A2 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | Bayer CropScience AG (DE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2008122375-A2 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179194-A1 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | CYP4X1, AADAC, CYP3A7 | KDM4E 1090/4885ALDH1A1 78/4885MAPT 3460/4885 |
| US-20130131017-A1 | BORON-CONTAINING SMALL MOLECULES | BCL6B, BCL6, RB1 | KDM4E 2393/4885ALDH1A1 4298/4885MAPT 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.