Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119172 | 0.94 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2USP2TP53 | |
| SCHEMBL3119026 | 0.81 | GAA (0.55) | NPC1RAB9ASMN1; SMN2USP2TP53 | |
| SCHEMBL3130513 | 0.80 | USP2 (0.56) | NPC1RAB9ASMN1; SMN2USP2FKBP1A | |
| SCHEMBL3129790 | 0.78 | MEN1 (0.35) | NPC1RAB9ASMN1; SMN2USP2KMT2A | |
| SCHEMBL7380150 | 0.74 | TP53 (0.64) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL3125826 | 0.74 | KDM4E (0.35) | NPC1RAB9ASMN1; SMN2USP2KMT2A | |
| SCHEMBL826085 | 0.73 | NPC1 (0.54) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL3121500 | 0.73 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL3119167 | 0.73 | NPSR1 (0.41) | NPC1RAB9ASMN1; SMN2USP2TP53 | |
| SCHEMBL2183432 | 0.72 | KDM4E (0.56) | SMN1; SMN2USP2ALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |