Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31217320 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL25433441 | 0.87 | ALDH1A1 (0.54) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL26890594 | 0.81 | ALDH1A1 (0.54) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL25434397 | 0.81 | ALDH1A1 (0.56) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL2520783 | 0.80 | PKM (0.47) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL30502815 | 0.80 | PKM (0.47) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL30502819 | 0.80 | PKM (0.47) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL2519991 | 0.79 | ALDH1A1 (0.54) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL25433128 | 0.79 | ALDH1A1 (0.54) | ALDH1A1PKMLMNAPOLBKMT2A | |
| SCHEMBL30502812 | 0.79 | ALDH1A1 (0.54) | ALDH1A1PKMLMNAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709729-A1 | PYRAZOLO[4,3-F]QUINAZOLINE DERIVATIVES AS MODULATORS OF G12D MUTANT KRAS USEFUL FOR THE TREATMENT OF CANCER | Jazz Pharmaceuticals Ireland Ltd. (IE) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024236452-A1 | PYRAZOLO[4,3-F]QUINAZOLINE DERIVATIVES AS MODULATORS OF G12D MUTANT KRAS USEFUL FOR THE TREATMENT OF CANCER | JAZZ PHARMACEUTICALS IRELAND LTD. (IE) | 2024-11-21 | — | — | WO | disclosed |