Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25171828 | 1.00 | HSD17B10 (0.42) | HSD17B10RPS6KA5KDM4ERAB9ANPC1 | |
| SCHEMBL553989 | 0.81 | RAB9A (0.56) | HSD17B10RPS6KA5KDM4ERAB9ANPC1 | |
| SCHEMBL12730928 | 0.76 | HSD17B10 (0.45) | HSD17B10RPS6KA5KDM4ERAB9ANPC1 | |
| SCHEMBL3438004 | 0.75 | RPS6KA5 (0.43) | HSD17B10RPS6KA5KDM4ERAB9ANPC1 | |
| SCHEMBL19763366 | 0.75 | CA12 (0.48) | HSD17B10RPS6KA5KDM4ERAB9ANPC1 | |
| SCHEMBL25171876 | 0.74 | NSD2 (0.34) | HSD17B10KDM4EALDH1A1TP53 | |
| SCHEMBL31220245 | 0.74 | NSD2 (0.34) | HSD17B10KDM4EALDH1A1TP53 | |
| SCHEMBL25168439 | 0.73 | CYP2A6 (0.44) | KDM4ERAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL15000600 | 0.73 | HSD17B10 (0.42) | HSD17B10RPS6KA5KDM4ERAB9ANPC1 | |
| SCHEMBL31220344 | 0.73 | CYP2A6 (0.44) | KDM4ERAB9ANPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118974035-A | 2-Aminoimidazole derivatives as PRMT5 inhibitors | 米拉蒂医疗股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| EP-4426690-A2 | 2-AMINO IMIDAZOLE DERIVATIVES AS PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |