Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25168439 | 1.00 | CYP2A6 (0.44) | CYP2A6HDAC1ALDH1A1TSHRKDM4E | |
| SCHEMBL19763372 | 0.75 | CA1 (0.51) | CYP2A6HDAC1ALDH1A1KDM4EMAPT | |
| SCHEMBL17315022 | 0.73 | HDAC1 (0.44) | CYP2A6HDAC1ALDH1A1TSHRKDM4E | |
| SCHEMBL25171828 | 0.73 | HSD17B10 (0.42) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL31220108 | 0.73 | HSD17B10 (0.42) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL25174516 | 0.71 | KDM4E (0.55) | HDAC1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL31220129 | 0.71 | KDM4E (0.55) | HDAC1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL28539017 | 0.71 | KMT2A (0.44) | CYP2A6HDAC1ALDH1A1KDM4EMAPT | |
| SCHEMBL28833063 | 0.70 | CYP2A6 (0.56) | CYP2A6ALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL14304918 | 0.70 | HDAC1 (0.45) | CYP2A6HDAC1ALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118974035-A | 2-Aminoimidazole derivatives as PRMT5 inhibitors | 米拉蒂医疗股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| EP-4426690-A2 | 2-AMINO IMIDAZOLE DERIVATIVES AS PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |