SCHEMBL31222022

SCHEMBL31222022

Cc1c(C(=O)N(CCCCO)Cc2n[nH]c3ccccc23)sc2ccc(-c3ccc(=O)n(C)c3)cc12

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC7 O00311 4/20 0.33
CREBBP Q92793 2/20 0.32
GSK3B P49841 2/20 0.31
IKBKB O14920 1/20 0.31
MAPK13 O15264 1/20 0.31
DAPK3 O43293 1/20 0.31
DYRK3 O43781 1/20 0.31
ROCK2 O75116 1/20 0.31
PRKD3 O94806 1/20 0.31
CDK1 P06493 1/20 0.31
PIM1 P11309 1/20 0.31
PRKACA P17612 1/20 0.31
CDK2 P24941 1/20 0.31
MAPK1 P28482 1/20 0.31
MAPK9 P45984 1/20 0.31
CSNK1D P48730 1/20 0.31
CDK8 P49336 1/20 0.31
CLK2 P49760 1/20 0.31
MAPK12 P53778 1/20 0.31
CSNK2A1 P68400 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31222027 0.85 LPAR1 (0.38) CREBBP
SCHEMBL31221948 0.83 CREBBP (0.41) CREBBP
SCHEMBL31221876 0.81
SCHEMBL31222041 0.80 SOS1 (0.33)
SCHEMBL31221946 0.80 PKM (0.31)
SCHEMBL31221910 0.79 BRD4 (0.33) MAPK1
SCHEMBL31222030 0.79 CREBBP (0.35) CREBBPPIM1CDK2CDK5
SCHEMBL31221993 0.77 HTR6 (0.35)
SCHEMBL31221985 0.76 BRD4 (0.37) MAPK1
SCHEMBL31222061 0.75 DPP4 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024232599-A1 NOVEL BENZOTHIOPHENE DERIVATIVE INHIBITING BET PROTEIN AND COMPOSITION FOR TREATMENT OF CANCER, USING SAME 주식회사 베노바이오 2024-11-14 WO disclosed