Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055712 | 1.00 | KDM4E (0.69) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL31225411 | 0.89 | KDM4E (0.73) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL15055437 | 0.89 | KDM4E (0.73) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL31247993 | 0.84 | KDM4E (0.71) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL15054998 | 0.84 | KDM4E (0.71) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL16216732 | 0.84 | RAB9A (0.48) | KDM4ERAB9APOLBMEN1KMT2A | |
| Limantrafin SCHEMBL25340427 | 0.82 | KDM4E (1.00) | KDM4ERAB9APOLBMEN1KMT2A | |
| Limantrafin SCHEMBL4638726 | 0.82 | KDM4E (1.00) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL30601045 | 0.82 | KDM4E (0.82) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL28064235 | 0.82 | KDM4E (0.82) | KDM4ERAB9APOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3332783-B1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2024-12-04 | — | — | EP | claimed |
| CN-119019324-A | Process for preparing aminodiaryl ethers and aminodiaryl ether hydrochlorides | 塞莱斯蒂亚生物技术股份公司 | 2024-11-26 | — | — | CN | disclosed |