SCHEMBL312269

SCHEMBL312269

Cc1c[nH]cnc1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoxidine SCHEMBL11601291 0.70
SCHEMBL12635219 0.70
SCHEMBL1771093 0.70
SCHEMBL2513 0.67
SCHEMBL16694372 0.65
SCHEMBL6169040 0.65
Iodide SCHEMBL13274496 0.65
Ethane SCHEMBL15300165 0.65
Ammonia Solution, Strong SCHEMBL28242554 0.65
SCHEMBL9381117 0.65 CYP3A4 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8541569-B2 Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA CHEMGENES CORPORATION (US) 2013-09-24 US claimed
EP-2560982-A2 PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION Chemgenes Corporation (US) 2013-02-27 EP claimed
US-20120149888-A1 SYNTHESIS OF ARA-2'-O-METHYL-NUCLEOSIDES, CORRESPONDING PHOSPHORAMIDITES AND OLIGONUCLEOTIDES INCORPORATING NOVEL MODIFICATIONS FOR BIOLOGICAL APPLICATION IN THERAPEUCTICS, DIAGNOSTICS, G- TETRAD FORMING OLIGONUCLEOTIDES AND APTAMERS CHEMGENES CORPORATION 2012-06-14 US claimed
EP-2398815-A2 SYNTHESIS OF ARA-2'-O-METHYL-NUCLEOSIDES, CORRESPONDING PHOSPHORAMIDITES AND OLIGONUCLEOTIDES INCORPORATING NOVEL MODIFICATIONS FOR BIOLOGICAL APPLICATION IN THERAPEUTICS, DIAGNOSTICS, G- TETRAD FORMING OLIGONUCLEOTIDES AND APTAMERS Chemgenes Corporation (US) 2011-12-28 EP claimed
WO-2011103468-A2 PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION CHEMGENES CORPORATION (US) 2011-08-25 WO claimed
US-20110137010-A1 PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, EFFICIENT RNA SYNTHESIS AND CONVENIENT INTRODUCTION OF 3'-END LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA CHEMGENES CORPORATION (US) 2011-06-09 US claimed
WO-2010096201-A2 SYNTHESIS OF ARA-2'-O-METHYL-NUCLEOSIDES, CORRESPONDING PHOSPHORAMIDITES AND OLIGONUCLEOTIDES INCORPORATING NOVEL MODIFICATIONS FOR BIOLOGICAL APPLICATION IN THERAPEUTICS, DIAGNOSTICS, G- TETRAD FORMING OLIGONUCLEOTIDES AND APTAMERS CHEMGENES CORPORATION (US) 2010-08-26 WO claimed
US-20240391945-A1 NUCLEIC ACID SYNTHESIS METHOD USING SEGMENT-TYPE AMIDITE NITTO DENKO CORPORATION (JP) 2024-11-28 US disclosed
EP-4089099-A1 NUCLEIC ACID SYNTHESIS METHOD USING SEGMENT-TYPE AMIDITE Nitto Denko Corporation (JP) 2022-11-16 EP disclosed
WO-2021141072-A1 NUCLEIC ACID SYNTHESIS METHOD USING SEGMENT-TYPE AMIDITE 日東電工株式会社 2021-07-15 WO disclosed
WO-2021080021-A1 METHOD FOR PRODUCING OLIGONUCLEOTIDE 日東電工株式会社 2021-04-29 WO disclosed
US-10508276-B2 Methods and compositions for the production of siRNAs CHILDREN'S MEDICAL CENTER CORPORATION (US) 2019-12-17 US disclosed
US-20190218255-A1 SCN9A ANTISENSE OLIGONUCLEOTIDES OLIPASS CORPORATION (KR) 2019-07-18 US disclosed
CN-1444595-A Deprotection of synthetic oligonucleotides using acrylonitrile scavenger AVECIA BIOTECHNOLOGY INC (US) 2003-09-24 CN disclosed
EP-1317466-A2 SYNTHONS FOR OLIGONUCLEOTIDE SYNTHESIS Avecia Biotechnology, Inc. (US) 2003-06-11 EP disclosed
EP-1294736-A1 DEPROTECTION OF SYNTHETIC OLIGONUCLEOTIDES USING AN ACRYLONITRILE SCAVENGER Avecia Biotechnology, Inc. (US) 2003-03-26 EP disclosed
WO-2003004512-A1 ACTIVATORS FOR OLIGONUCLEOTIDE SYNTHESIS AVECIA BIOTECHNOLOGY INC. (US) 2003-01-16 WO disclosed
US-20020072593-A1 Method of preventing modification of synthetic oligonucleotides AVECIA BIOTECHNOLOGY INC. 2002-06-13 US disclosed
WO-2002020543-A2 SYNTHONS FOR OLIGONUCLEOTIDE SYNTHESIS AVECIA BIOTECHNOLOGY INC. (US) 2002-03-14 WO disclosed
WO-2001096358-A1 DEPROTECTION OF SYNTHETIC OLIGONUCLEOTIDES USING ACRYLONITRILE SCAVENGER AVECIA BIOTECHNOLOGY, INC. (US) 2001-12-20 WO disclosed