SCHEMBL31228121

SCHEMBL31228121

Nc1ncnc2c1ccn2[C@@H]1O[C@](F)(CO)[C@@H](O)[C@]1(F)Cl

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ADK P55263 1/20 0.46
PRMT5 O14744 18/20 0.43
WDR77 Q9BQA1 14/20 0.43
METTL3 Q86U44 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31228240 0.86 PRMT5 (0.52) ADKPRMT5WDR77
SCHEMBL19859757 0.83 PRMT5 (0.46) ADKPRMT5WDR77METTL3
SCHEMBL19859341 0.83 PRMT5 (0.46) ADKPRMT5WDR77METTL3
SCHEMBL21078499 0.83 PRMT5 (0.44) ADKPRMT5WDR77
SCHEMBL31228199 0.82 ADK (0.40) ADKPRMT5WDR77METTL3
SCHEMBL19379667 0.82 PRMT5 (0.43) ADKPRMT5WDR77
SCHEMBL19379660 0.82 PRMT5 (0.43) ADKPRMT5WDR77
SCHEMBL18480770 0.79 ADK (0.52) ADKPRMT5WDR77METTL3
SCHEMBL18470916 0.79 ADK (0.52) ADKPRMT5WDR77METTL3
SCHEMBL31228198 0.79 ADK (0.57) ADKPRMT5WDR77METTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4705313-A2 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS The Scripps Research Institute (US) 2026-03-11 EP claimed
WO-2024227159-A2 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS THE SCRIPPS RESEARCH INSTITUTE (US) 2024-10-31 WO claimed
EP-4705313-A2 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS The Scripps Research Institute (US) 2026-03-11 EP disclosed
WO-2024227159-A2 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS THE SCRIPPS RESEARCH INSTITUTE (US) 2024-10-31 WO disclosed