Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228613 | 0.92 | TSHR (0.36) | TSHRMAPTALDH1A1POLBMEN1 | |
| SCHEMBL31228306 | 0.78 | MMP13 (0.40) | MEN1KMT2ASTAT3MMP2MMP9 | |
| SCHEMBL31228300 | 0.78 | MMP13 (0.40) | MEN1KMT2ASTAT3MMP2MMP9 | |
| SCHEMBL31228598 | 0.76 | HTT (0.36) | MAPTALDH1A1HRH3MEN1KMT2A | |
| SCHEMBL31228458 | 0.75 | GRIN2B (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31228239 | 0.75 | MMP13 (0.39) | MAPTPOLBMEN1KMT2ALMNA | |
| SCHEMBL31228427 | 0.72 | MMP13 (0.37) | MEN1KMT2AMMP13 | |
| SCHEMBL31228367 | 0.71 | MMP13 (0.40) | MEN1KMT2ASTAT3MMP2MMP9 | |
| SCHEMBL31228678 | 0.70 | MMP13 (0.37) | MEN1KMT2ALMNANPSR1MMP2 | |
| SCHEMBL31228389 | 0.68 | MMP13 (0.40) | MEN1KMT2ASTAT3MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |