Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228598 | 0.86 | HTT (0.36) | MEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL31228613 | 0.82 | TSHR (0.36) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31228241 | 0.77 | YAP1 (0.39) | MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL31228227 | 0.77 | YAP1 (0.39) | MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL31228299 | 0.75 | TSHR (0.35) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31228242 | 0.72 | ACHE (0.39) | MEN1KMT2AATMCYP3A4 | |
| SCHEMBL31228285 | 0.69 | KLK7 (0.37) | MEN1KMT2AALDH1A1SMN1; SMN2PTPN1 | |
| SCHEMBL31228531 | 0.69 | KLK7 (0.39) | KMT2A | |
| SCHEMBL31153940 | 0.67 | YAP1 (0.39) | ATMSMN1; SMN2 | |
| SCHEMBL28952807 | 0.66 | SMN1; SMN2 (0.55) | GRIN2BMEN1KMT2ASMN1; SMN2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |