Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.42 |
| ▸ | PREP | P48147 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228393 | 0.89 | KLK7 (0.44) | ACE2PREPALDH1A1FKBP1A | |
| SCHEMBL31228368 | 0.83 | MAPT (0.40) | ALDH1A1 | |
| SCHEMBL31228420 | 0.79 | TACR1 (0.42) | ALDH1A1 | |
| SCHEMBL31228745 | 0.77 | KLK7 (0.39) | ACE2PREPALDH1A1 | |
| SCHEMBL31228607 | 0.77 | ATM (0.31) | — | |
| SCHEMBL31153839 | 0.73 | JAK2 (0.46) | ALDH1A1 | |
| SCHEMBL31153754 | 0.73 | JAK2 (0.46) | ALDH1A1 | |
| SCHEMBL31153873 | 0.73 | PREP (0.52) | ACE2PREPALDH1A1TSHRCTRB1 | |
| SCHEMBL23298100 | 0.73 | MEN1 (0.41) | ALDH1A1SIGMAR1CYP2C9CYP2C19 | |
| SCHEMBL23298099 | 0.73 | MEN1 (0.41) | ALDH1A1SIGMAR1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |