Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.41 |
| ▸ | PREP | P48147 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228368 | 0.95 | MAPT (0.40) | KLK7MEN1KMT2AMAPTPARP1 | |
| SCHEMBL31228420 | 0.89 | TACR1 (0.42) | KLK7MEN1KMT2AMAPTPARP1 | |
| SCHEMBL31228332 | 0.89 | ACE2 (0.42) | ACE2PREPALDH1A1FKBP1A | |
| SCHEMBL31228745 | 0.87 | KLK7 (0.39) | KLK7ACE2PREPMEN1KMT2A | |
| SCHEMBL31228488 | 0.86 | P2RX7 (0.41) | KLK7ACE2MEN1KMT2AMAPT | |
| SCHEMBL31228440 | 0.82 | AGTR2 (0.40) | KLK7MEN1KMT2AMAPTPARP1 | |
| SCHEMBL31153754 | 0.82 | JAK2 (0.46) | MEN1KMT2AMAPTPARP1L3MBTL1 | |
| SCHEMBL31153839 | 0.82 | JAK2 (0.46) | MEN1KMT2AMAPTPARP1L3MBTL1 | |
| SCHEMBL31228526 | 0.80 | TACR1 (0.42) | MEN1KMT2AMAPTPARP1L3MBTL1 | |
| SCHEMBL31153873 | 0.80 | PREP (0.52) | KLK7ACE2PREPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |