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SCHEMBL31228607

SCHEMBL31228607

COC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)O)[C@@H]1CO

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.31
▸ POLB P06746 1/20 0.31
▸ RAB9A P51151 1/20 0.30
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31228414 0.85 KMT2A (0.32) KMT2A
SCHEMBL31228332 0.77 ACE2 (0.42) —
SCHEMBL31228509 0.76 MMP3 (0.31) KMT2A
SCHEMBL31228362 0.76 MMP3 (0.31) KMT2A
SCHEMBL31228189 0.76 MMP3 (0.31) KMT2A
SCHEMBL31228598 0.74 HTT (0.36) MEN1KMT2A
SCHEMBL31228461 0.72 ALDH1A1 (0.30) KMT2A
SCHEMBL23297851 0.71 SMN1; SMN2 (0.37) POLBMEN1KMT2A
SCHEMBL23297855 0.71 SMN1; SMN2 (0.37) POLBMEN1KMT2A
SCHEMBL23297854 0.71 SMN1; SMN2 (0.37) POLBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4688789-A1 MACROCYCLIC RAS INHIBITORS Revolution Medicines, Inc. (US) 2026-02-11 — — EP disclosed
WO-2024211663-A9 MACROCYCLIC RAS INHIBITORS Revolution Medicines, Inc. (US) 2025-01-30 — — WO disclosed
WO-2024211663-A1 CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS Revolution Medicines, Inc. (US) 2024-10-10 — — WO disclosed