Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020025 | 0.81 | CA12 (0.38) | CA14CA12AAK1MMP13 | |
| SCHEMBL13682813 | 0.81 | CA12 (0.38) | CA14CA12AAK1MMP13 | |
| SCHEMBL21492497 | 0.80 | CA12 (0.36) | CA14CA12CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL21492499 | 0.80 | CA12 (0.36) | CA14CA12CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL28334313 | 0.80 | CA12 (0.37) | CA14CA12AAK1MMP13 | |
| SCHEMBL30878165 | 0.78 | THRB (0.38) | CA14CA12TSHRTHRBAAK1 | |
| SCHEMBL25385348 | 0.77 | CA12 (0.36) | CA14CA12AAK1 | |
| SCHEMBL25980518 | 0.77 | GAA (0.38) | CA14CA12TSHRTHRB | |
| SCHEMBL20462074 | 0.76 | ALOX5 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4AAK1 | |
| SCHEMBL24439779 | 0.76 | ALOX5 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |