Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.65 |
| ▸ | MKNK2 | Q9HBH9 | 12/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768271 | 1.00 | MKNK1 (0.65) | MKNK1MKNK2CHEK2CYP2A6ALDH1A1 | |
| SCHEMBL4768283 | 0.85 | KMT2A (0.57) | MKNK1MKNK2SIRT6GSK3BADORA3 | |
| SCHEMBL1810092 | 0.84 | MKNK1 (0.64) | MKNK1MKNK2CHEK2CYP2A6ALDH1A1 | |
| SCHEMBL2927582 | 0.84 | HIF1A (0.53) | MKNK1MKNK2CHEK2ALDH1A1GSK3B | |
| SCHEMBL30617944 | 0.82 | GSK3B (0.54) | MKNK1MKNK2CHEK2GSK3BADORA3 | |
| SCHEMBL933914 | 0.81 | MKNK1 (0.59) | MKNK1MKNK2CHEK2CYP2A6ALDH1A1 | |
| SCHEMBL30761107 | 0.81 | MKNK1 (0.59) | MKNK1MKNK2CHEK2CYP2A6ALDH1A1 | |
| SCHEMBL29186573 | 0.81 | GSK3B (0.52) | MKNK1MKNK2CHEK2GSK3BADORA3 | |
| SCHEMBL19376938 | 0.79 | MKNK1 (0.55) | MKNK1MKNK2CHEK2CYP2A6ALDH1A1 | |
| SCHEMBL5320806 | 0.79 | MKNK1 (0.68) | MKNK1MKNK2CYP2A6ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024233280-A1 | HETEROBIFUNCTIONAL SMALL MOLECULES THAT DEUBIQUITINYLATE AND STABILIZE TARGET PROTEINS BY RECRUITING USP7 | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2024-11-14 | — | — | WO | disclosed |