SCHEMBL1810092

SCHEMBL1810092

O=C(O)c1ccc(-c2cccnc2)cn1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 8/20 0.64
MKNK2 Q9HBH9 8/20 0.64
KMO O15229 2/20 0.59
CYP2A6 P11509 3/20 0.54
ALDH1A1 P00352 3/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
PIM1 P11309 1/20 0.49
PIM2 Q9P1W9 1/20 0.49
APP P05067 1/20 0.48
GAA P10253 1/20 0.48
HCAR3 P49019 1/20 0.48
HCAR2 Q8TDS4 1/20 0.48
P4HA1 P13674 1/20 0.48
MIF P14174 1/20 0.48
P4HTM Q9NXG6 1/20 0.48
KDM4E B2RXH2 1/20 0.47
DHODH Q02127 1/20 0.47
CHEK2 O96017 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29929320 0.85 HIF1A (0.55) ALDH1A1P4HA1MIFP4HTMKDM4E
SCHEMBL71034 0.85 HIF1A (0.55) ALDH1A1P4HA1MIFP4HTMKDM4E
SCHEMBL13731115 0.84 P4HTM (0.64) ALDH1A1CYP1A2CYP3A4P4HA1MIF
SCHEMBL4768271 0.84 MKNK1 (0.65) MKNK1MKNK2CYP2A6ALDH1A1CYP1A2
SCHEMBL31228498 0.84 MKNK1 (0.65) MKNK1MKNK2CYP2A6ALDH1A1CYP1A2
Hydrochloric Acid SCHEMBL28470042 0.83 HIF1A (0.54) ALDH1A1P4HA1MIFP4HTMKDM4E
SCHEMBL31512829 0.81 P4HTM (0.52) MKNK1MKNK2ALDH1A1HCAR2P4HA1
Ethylene SCHEMBL29031104 0.81 HIF1A (0.53) ALDH1A1P4HA1MIFP4HTMKDM4E
SCHEMBL13188221 0.81 KMO (0.63) MKNK1MKNK2KMOCYP2A6ALDH1A1
SCHEMBL20448087 0.81 KMO (0.67) MKNK1MKNK2KMOCYP2A6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3885340-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2024-11-27 EP disclosed
EP-3885340-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2021-09-29 EP disclosed
US-11046713-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2021-06-29 US disclosed
EP-3369732-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2021-05-26 EP disclosed
US-20200299307-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2020-09-24 US disclosed
US-10711013-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2020-07-14 US disclosed
US-20190100536-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2019-04-04 US disclosed
US-10118933-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2018-11-06 US disclosed
EP-3369732-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2018-09-05 EP disclosed
EP-3056485-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2018-05-09 EP disclosed
EP-2699561-B1 ANDROGEN RECEPTOR MODULATING CARBOXAMIDES ORION CORP (FI) 2015-06-03 EP disclosed
US-8975254-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2015-03-10 US disclosed
US-8921378-B2 Androgen receptor modulating carboxamides ORION CORPORATION (FI) 2014-12-30 US disclosed
EP-2493858-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2014-07-02 EP disclosed
EP-2699561-A1 ANDROGEN RECEPTOR MODULATING CARBOXAMIDES Orion Corporation (FI) 2014-02-26 EP disclosed
WO-2012143599-A1 ANDROGEN RECEPTOR MODULATING CARBOXAMIDES ORION CORPORATION (FI) 2012-10-26 WO disclosed
US-20120225867-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2012-09-06 US disclosed
EP-2493858-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS Orion Corporation (FI) 2012-09-05 EP disclosed
WO-2011051540-A9 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2012-06-21 WO disclosed
WO-2011051540-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2011-05-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10118933-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG MKNK1 2453/4885MKNK2 1977/4885KMO 3655/4885
US-10711013-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG MKNK1 2453/4885MKNK2 1977/4885KMO 3655/4885
US-20200299307-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG MKNK1 2453/4885MKNK2 1977/4885KMO 3655/4885
US-20190100536-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG MKNK1 2453/4885MKNK2 1977/4885KMO 3655/4885
US-11046713-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG MKNK1 2453/4885MKNK2 1977/4885KMO 3655/4885
US-20120225867-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG MKNK1 2453/4885MKNK2 1977/4885KMO 3655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.