Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.60 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | PTGIR | P43119 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | NPR3 | P17342 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482869 | 0.87 | EGFR (0.55) | SCN9ASRC | |
| SCHEMBL913987 | 0.82 | SYK (0.65) | SCN9AMAP3K5KCNH2AURKBSYK | |
| SCHEMBL3240538 | 0.75 | SCN9A (1.00) | SCN9AKCNH2SCN5A | |
| SCHEMBL3122959 | 0.74 | MAP3K5 (0.55) | SCN9AMAP3K5KCNH2SCN5AABCG2 | |
| SCHEMBL3243500 | 0.74 | MAP3K5 (0.60) | SCN9AMAP3K5KCNH2SCN5AABCG2 | |
| SCHEMBL3249544 | 0.72 | SCN9A (0.75) | SCN9AKCNH2SCN5A | |
| SCHEMBL12443884 | 0.71 | MAP3K5 (0.63) | MAP3K5ABCG2JAK2AURKAAURKB | |
| SCHEMBL3247315 | 0.70 | SCN9A (0.79) | SCN9AKCNH2SCN5A | |
| SCHEMBL6998351 | 0.70 | SMN1; SMN2 (0.57) | PTGIRKDM1ASMN1; SMN2NPSR1 | |
| SCHEMBL3240604 | 0.69 | SCN9A (0.78) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |