Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219871 | 0.86 | POLB (0.72) | MAP3K5AURKAAURKBPOLBJAK2 | |
| SCHEMBL3246720 | 0.86 | POLB (0.68) | MAP3K5AURKAAURKBPOLBJAK2 | |
| SCHEMBL28406679 | 0.84 | EGFR (0.51) | MAP3K5AURKAAURKBSCN9AKCNH2 | |
| SCHEMBL28400866 | 0.83 | EGFR (0.61) | SRC | |
| SCHEMBL30423172 | 0.83 | EGFR (0.61) | SRC | |
| SCHEMBL3243775 | 0.81 | SCN9A (0.55) | MAP3K5AURKAAURKBSCN9AKCNH2 | |
| SCHEMBL2443952 | 0.80 | AURKA (0.54) | MAP3K5AURKAAURKBSCN9AKCNH2 | |
| SCHEMBL27705134 | 0.80 | RHOA (0.62) | AURKAABL1ALDH1A1SYKFLT3 | |
| SCHEMBL28406621 | 0.79 | ABL1 (0.60) | POLBABL1PDGFRBSRCPDGFRA | |
| SCHEMBL2355018 | 0.79 | SCN9A (0.62) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |