Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31325224 | 0.86 | FUCA1 (0.46) | FUCA1GBA1GAAMEN1KMT2A | |
| SCHEMBL4482745 | 0.86 | FUCA1 (0.46) | FUCA1GBA1GAAMEN1KMT2A | |
| SCHEMBL8388967 | 0.78 | FUCA1 (0.44) | FUCA1GBA1POLBGAAALDH1A1 | |
| SCHEMBL5654095 | 0.76 | ALDH1A1 (0.44) | FUCA1GBA1POLBMEN1KMT2A | |
| SCHEMBL5465323 | 0.76 | ALDH1A1 (0.44) | FUCA1GBA1POLBMEN1KMT2A | |
| SCHEMBL5870766 | 0.75 | ACHE (0.47) | MEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL17137260 | 0.75 | ACHE (0.47) | MEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL21480155 | 0.75 | ALDH1A1 (0.43) | FUCA1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL21480154 | 0.75 | ALDH1A1 (0.43) | FUCA1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL19779412 | 0.75 | ALDH1A1 (0.43) | FUCA1POLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705302-A1 | PYRIDO[4,3-D]PYRIMIDINE DERIVATIVES AS MUTANT KRAS G12C INHIBITORS FOR THE TREATMENT OF CANCER | Frontier Medicines Corporation (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024229447-A1 | PYRIDO[4,3-D]PYRIMIDINE DERIVATIVES AS MUTANT KRAS G12C INHIBITORS FOR THE TREATMENT OF CANCER | FRONTIER MEDICINES CORPORATION (US) | 2024-11-07 | — | — | WO | disclosed |