Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.63 |
| ▸ | JAK1 | P23458 | 4/20 | 0.63 |
| ▸ | ULK1 | O75385 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26686431 | 0.90 | JAK2 (0.63) | JAK2JAK1ULK1MAPK8MAPK10 | |
| SCHEMBL31240484 | 0.90 | JAK2 (0.63) | JAK2JAK1ULK1MAPK8MAPK10 | |
| SCHEMBL31420124 | 0.89 | JAK2 (0.61) | JAK2JAK1ULK1NTRK1KIT | |
| SCHEMBL26686370 | 0.89 | JAK2 (0.61) | JAK2JAK1ULK1NTRK1KIT | |
| SCHEMBL31240431 | 0.88 | NPC1 (0.48) | JAK2JAK1ULK1MAPK8MAPK10 | |
| SCHEMBL31240518 | 0.87 | PIK3C3 (0.48) | JAK2JAK1ULK1MAPK8KDR | |
| SCHEMBL31240612 | 0.86 | ROCK1 (0.53) | JAK2JAK1ULK1MAPK8LRRK2 | |
| SCHEMBL31240611 | 0.86 | ROCK1 (0.53) | JAK2JAK1ULK1MAPK8LRRK2 | |
| SCHEMBL31240265 | 0.84 | JAK2 (0.61) | JAK2JAK1MAPK8MAPK10AURKA | |
| SCHEMBL30633352 | 0.83 | JAK2 (0.56) | JAK2JAK1NTRK1KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705291-A1 | IKK-ALPHA INHIBITORS | Cancer Research Technology Limited (GB) | 2026-03-11 | — | — | EP | claimed |
| WO-2024228035-A1 | IKK-ALPHA INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-11-07 | — | — | WO | claimed |
| EP-4705291-A1 | IKK-ALPHA INHIBITORS | Cancer Research Technology Limited (GB) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024228035-A1 | IKK-ALPHA INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-11-07 | — | — | WO | disclosed |