Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803258 | 0.81 | XDH (0.58) | XDHMAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3119145 | 0.73 | SRC (0.40) | XDHPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5819432 | 0.73 | XDH (0.43) | XDHMAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3119106 | 0.71 | XDH (0.40) | XDHMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6667087 | 0.70 | MAPT (0.41) | XDHMAPTMEN1KMT2ANPC1 | |
| SCHEMBL3868995 | 0.69 | XDH (1.00) | XDHMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL31736051 | 0.69 | NPC1 (0.45) | XDHMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL5118469 | 0.68 | PI4KA (0.63) | XDHMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL14693600 | 0.68 | XDH (0.46) | XDHMAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL15708517 | 0.68 | XDH (0.52) | XDHMAPTPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829570-B2 | Substituted 4-amino isoxazolo[5,4-d]pyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-11-09 | — | — | US | disclosed |
| US-20100041676-A1 | Kinase inhibitors | ABBVIE INC. | 2010-02-18 | — | — | US | disclosed |
| US-20030225098-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-12-04 | — | — | US | disclosed |
| US-20030199525-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199525-A1 | Kinase inhibitors | MAP3K19, MAP3K9, MAP3K1 | XDH 1187/4885MAPT 4355/4885PIK3CD 144/4885 |
| US-20030225098-A1 | Kinase inhibitors | MAP3K19, MAP3K9, MAP3K1 | XDH 1215/4885MAPT 4419/4885PIK3CD 151/4885 |
| US-20100041676-A1 | Kinase inhibitors | MAP3K19, MAP3K20, MAP3K6 | XDH 1780/4885MAPT 3351/4885PIK3CD 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.