SCHEMBL31241237

SCHEMBL31241237

COC(=O)c1ccc(C)c(OCc2ccccc2)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.59
HPGD P15428 2/20 0.59
RAB9A P51151 2/20 0.59
MAPT P10636 2/20 0.59
L3MBTL1 Q9Y468 2/20 0.59
RXRA P19793 2/20 0.57
RXRB P28702 1/20 0.57
RXRG P48443 1/20 0.57
SMPD1 P17405 2/20 0.56
HDAC1 Q13547 1/20 0.56
HDAC8 Q9BY41 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
SMN1; SMN2 Q16637 3/20 0.54
NPC1 O15118 1/20 0.54
NOTUM Q6P988 1/20 0.53
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
PPIA P62937 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16929834 1.00 LMNA (0.59) LMNAHPGDRAB9AMAPTL3MBTL1
SCHEMBL30809647 0.94 LMNA (0.64) LMNAHPGDRAB9AMAPTL3MBTL1
SCHEMBL20059720 0.89 LMNA (0.59) LMNAHPGDRAB9AMAPTL3MBTL1
SCHEMBL69503 0.89 RXRA (0.57) LMNAHPGDRAB9AMAPTL3MBTL1
SCHEMBL3245222 0.88 SMPD1 (0.67) LMNAHPGDRAB9AMAPTL3MBTL1
SCHEMBL22169851 0.88 MAPT (0.55) LMNARAB9AMAPTL3MBTL1SMN1; SMN2
SCHEMBL69666 0.87 RXRA (0.70) HPGDRAB9ARXRARXRBRXRG
SCHEMBL21588079 0.86 HPGD (0.68) LMNAHPGDRAB9AMAPTL3MBTL1
SCHEMBL2188210 0.86 SMPD1 (0.76) LMNAHPGDRAB9AMAPTRXRA
SCHEMBL2063068 0.86 SMN1; SMN2 (0.73) LMNAHPGDRAB9AMAPTRXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712958-A2 USE OF UROLITHIN DERIVATIVES IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS Vandria SA (CH) 2026-03-25 EP disclosed
CN-119948002-A Urolithin derivatives and therapeutic use 范徳利亚股份公司 2025-05-06 CN disclosed
WO-2024236367-A2 USE OF UROLITHIN DERIVATIVES IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS VANDRIA SA (CH) 2024-11-21 WO disclosed